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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN3 All Species: 26.97
Human Site: S818 Identified Species: 74.17
UniProt: P26045 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26045 NP_001138840.1 913 103990 S818 D H G V P D D S S D F L E F V
Chimpanzee Pan troglodytes XP_520179 913 103998 S818 D H G V P D D S S D F L E F V
Rhesus Macaque Macaca mulatta XP_001107076 913 104134 S818 D H G V P D D S S D F L E F V
Dog Lupus familis XP_853516 913 104010 S818 D H G V P D D S S D F L E F V
Cat Felis silvestris
Mouse Mus musculus A2ALK8 913 103878 S818 D H G V P D D S S D F L E F V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506800 952 108609 S857 D H G V P D D S S D F L E F V
Chicken Gallus gallus XP_419047 1136 128587 S1041 D H G V P D D S M D F L E F V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio O57457 619 70690 R528 D P N Q R R S R H R S R S R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P28191 1026 115075 P927 D H G V P D D P K H F I Q F V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 98 94.1 N.A. 92 N.A. N.A. 79.5 63.1 N.A. 22.7 N.A. N.A. N.A. 36.5 N.A.
Protein Similarity: 100 99.6 98.9 97.1 N.A. 96.3 N.A. N.A. 86.8 71.3 N.A. 38.1 N.A. N.A. N.A. 53.7 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. 100 93.3 N.A. 6.6 N.A. N.A. N.A. 66.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 100 93.3 N.A. 6.6 N.A. N.A. N.A. 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 100 0 0 0 0 89 89 0 0 78 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 78 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 89 0 0 89 0 % F
% Gly: 0 0 89 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 89 0 0 0 0 0 0 12 12 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 78 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % M
% Asn: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 12 0 0 89 0 0 12 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 12 0 0 0 0 0 0 0 0 12 0 0 % Q
% Arg: 0 0 0 0 12 12 0 12 0 12 0 12 0 12 0 % R
% Ser: 0 0 0 0 0 0 12 78 67 0 12 0 12 0 12 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 89 0 0 0 0 0 0 0 0 0 0 89 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _